autoimmunity microbiome program
Systemic Lupus Erythematosus (SLE)
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease where the immune system attacks multiple organs, including skin, joints, kidneys, heart, and brain.
Overview
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease where the immune system attacks multiple organs, including skin, joints, kidneys, heart, and brain. It affects about 1 in 1,000 Australians, mostly women aged 15–45 (Lupus Australia, 2023).
Common Misunderstandings
Lupus is often called “the great imitator” because its symptoms mimic other conditions, leading to delays in diagnosis. Many patients feel unseen because they “don’t look sick” despite severe fatigue or pain.
How is Lupus Linked to Your Microbiome?
- SLE patients often show reduced gut microbial diversity and altered species composition (e.g., lower Firmicutes, higher Bacteroidetes) (Hevia et al., 2014).
- Dysbiosis may promote immune activation via increased gut permeability and molecular mimicry (Azzouz et al., 2019).
- Some lupus flares have been associated with changes in oral microbiota, suggesting a gut–oral–immune connection (Corrêa et al., 2017).
- Animal studies show that modifying gut microbiota can influence lupus-like disease severity, but human trials are scarce.
Been diagnosed with Lupus?
Addressing the microbiome might help you.
The Microbiome Clinic™ offers thorough testing and tailored microbiome treatment plans grounded in science.
